Jamestown Regional Medical Center, formerly Fentress County General Hospital, admitted the first patient on March 1, 1960. The hospital had 39 beds. As the community grew, there became a need for a larger facility. On January 1, 1965, a 31-bed expansion opened.
During the year of 1982, the hospital added a Physical Therapy Department, Nuclear Medicine and Ultrasound Department; and expansion of the Emergency Department from a one bed examination area to four beds.
Further improvements were implemented in 1984. A new dining area was constructed. Three outpatient rooms were added to the Emergency Department to provide an Outpatient Treatment Area. In 1986, an area was constructed to house the Business Office and Pharmacy. In 1987, a 14 bed Skilled Nursing Facility opened.